The paper designs and implements a wireless temperature and humidity acquisition system which is based on the Z-Stack protocol stack and ZigBee technology, with CC2530 rf transceiver chip and DHT22 digital temperature and humidity sensor as the core, and in the IAR environment with the method of upper machine software with GUI to display temperature and humidity changes in terminal intuitively. This paper mainly expounds the system structure design, temperature and humidity data acquisition process and graphical interface monitoring implementation. The experimental result shows that the system of temperature and humidity data acquisition is not only real-time and effective, good scalability, and has high reliability and excellent stability.