This article presents an ultracentrifuge temperature control module, which uses fuzzy PID control algorithm. Through auto-tuning PID parameters using fuzzy logic, the controller adjust input voltage to the semiconductor cooling piece to control centrifugal room temperature accurately and rapidly. Simulink is used to simulate the proposed fuzzy PID controller. The simulation results show that the proposed controller has both the advantage of PID controller and fuzzy controller and it is very efficient in controlling the centrifuge temperature.