Through detailed analysis on the management of university research, combined with the characteristics of scientific research work in higher vocational college, this paper designs and develops a scientific research management information system based on the mixed model of C/S and B/S. On the actual need of scientific research business processes and the staff in higher vocational college, this paper designs the corresponding function modules and operating processes. The application of regular expressions technology is used to extract the information of staff's paper from CNKI directly and it saves the data entry time. The system has been put into operation for two years. The result of use shows that the system makes the scientific research management more standardized and efficiency.