Aiming at the daily security of students in colleges and universities, in this study, we proposed and designed a set of security management system for college students based on ThinkPHP framework and Workerman framework, focusing on the whole process from the data receiving, the data storage, and ultimately to the realization of data display and its application. According to the principle of symmetric encryption algorithm, we set the encryption rules independently, improving the system security. The system has the advantages of clear power design, efficient code operation, and high safety. With this system, administrators can query the students' basic information, current real-time location, daily attendance record, and alarm data, which has effectively solved the problem of the safety management of students in colleges and universities.